Introduction: Chronic hemodialysis aims to replace renal function and provides an extension of life expectancy, however, complications do occur and they can be serious even fatal. Knowing the complications can enable a better prognostic evaluation and use of an intervention approach. These can be identified when performing anamnesis and physical examination, as well as, with greater precision, by means of renal and cardiac biomarkers and imaging tests.

Objectives: to identify valid blood biomarkers to detect heart failure and kidney failure associated with kidney disease and hemodialysis.